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What is Pyroluria


The Silent Disorder 

What is Pyroluria, Pyrrole Disorder & Kryptopyrroles?

Pyroluria is known by many different names including Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Pyrroluria, Pyrolle Disorder, Mauve Factor and Hemepyrrole. Pyroluria can best be described as the abnormal synthesis and metabolism of the oxygen carrying molecule in your blood, called haemoglobin. As with all cells in your body there are waste or by-products produced and the by-product of haemoglobin is a metabolite called hydroxyhemopyrrolin-2-one (HPL) also known as Pyrrole.


The metabolite was originally thought to be a Kryptopyrrole but further studies have proven this not to be the case.

People who suffer from Pyroluria produce excessive amounts of these Pyrroles which bind to or inhibit the nutrients; Zinc (1-7), Biotin 8, and the Omega 6 Fat GLA from reaching their targets within your body. This effectively renders these nutrients unavailable to you.


Supplementation with these nutrients not only helps to reduce your Pyrrole levels but also the severity of the conditions, signs, and symptoms listed below.

Conditions Associated With Pyroluria


  • Panic /Anxiety Disorder            

  • Neurosis/Neurotic


  • Depression

  • Post Natal Depression

  • Alcoholism (Addictions) 

  • Down Syndrome

  • Schizophrenia

  • Allergies

  • Epilepsy

  • Substance Abuse

  • Asperger’s Syndrome

  • Learning Difficulties

  • Tourette’s Syndrome

  • Autism

  • Lung Cancer

  • Violent Offenders

  • Bi-Polar Disorder

  • Manic Depression

  • Lyme Disease 

What to do next?

As you can see pyroluria is a complex health issue and whereas treatment with the relevant nutrients will help to reduce the symptoms associated with pyroluria, it has not addressed the underlying causes. So any treatment protocol for pyroluria needs to not only support the nutritional deficiencies caused by an elevation of pyrroles, but to also identify and treat what has caused these in the first place. 



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